Corneal diseases are among the major causes of global blindness, second only to cataracts in overall significance. The etiology of corneal blindness includes various infectious and inflammatory eye diseases that cause corneal scarring, which ultimately leads to functional blindness. Anatomically, the cornea is the outermost layer of the eye and is primarily responsible for light refraction, allowing for central and peripheral vision. In cases where less invasive treatments for corneal disease fail, corneal transplant is indicated, which has the highest success rate of any transplant procedure. The simplest form of corneal transplant, Penetrating Keratoplasty (PKP), is performed by transplanting a donor cornea from a cadaver. The authors review a more complex form of corneal transplant, Osteo-Odonto Keratoprosthesis (OOKP), which is a two stage procedure wherein dental and buccal tissue is auto-transplanted to replace the cornea. This review
comprises relevant anatomy, the procedure, surgical interprofessionalism, indications, contraindications, complications, patient outcomes and future scope of OOKP.